Symptoms of Withdrawal

Major withdrawal symptoms peak between 24–48 hours after the last dose of heroin and subside after about a week. However, some people have shown persistent withdrawal signs for many months.

Prescription Opioids

• Muscle and bone pain
• Cold flashes with goose bumps (“cold turkey”)
• Vomiting
• Inability to sleep
• Restlessness
• Diarrhea
• Involuntary leg movements

Heroin

• Muscle and bone pain
• Cold flashes with chills
• Vomiting
• Inability to sleep
• Restlessness
• Kicking movements
• Strong craving for the drug

Fentanyl

• Nausea
• vomiting
• diarrhea
• anxiety
• shivering

^{Source: U.S. Department of Health and Human Services, Heroin Research Report Series. View here; Food and Drug Administration. View here.}